Difference Between Serum and Plasma, TAGUAS SIDE HUSTLES

What’s the Difference Between Serum and Plasma?

Serum and plasma are two different preparations of blood that can be used for a variety of research purposes. The difference lies in the process by which the samples are prepared.

Plasma is collected from whole blood that has been allowed to clot before being mixed with an anticoagulant and centrifuged. The resulting supernatant, designated plasma, is carefully removed.

When it comes to blood, there are two main components that are often talked about: plasma and serum. Both plasma and serum are important for medical research and diagnosis, but they are not the same thing. In this article, we will discuss the differences between plasma and serum.

When it comes to blood testing, you may have heard the terms “plasma” and “serum” used interchangeably, but they are not the same thing. While both are blood components, they have distinct differences that can impact their usefulness in medical diagnosis and treatment. In this blog post, we will explore the differences between plasma and serum and how they are used in medical settings.


Proteins are large, complex molecules that play a significant role in the structure and function of our cells. These molecules are largely composed of amino acids, carbohydrates, carbon, hydrogen, oxygen, and sometimes nitrogen.

There are tens of thousands of proteins that make up the human body. Each has a unique three-dimensional structure that defines its function.

These proteins are found throughout the body in organs and tissues that need to carry out functions like transporting nutrients, oxygen, or metabolic wastes. They also regulate the body’s temperature and pH levels by interacting with acidic and basic substances.

When scientists began studying the proteomes of serum and plasma, they were quickly impressed with the dynamic range of protein concentrations present in these fluids. They believed that these samples could provide new biomarkers that would help identify conditions such as cancer and neurodegenerative diseases.


Electrolytes are chemical elements that can naturally hold a positive or negative charge. When dissolved in water, they conduct electricity and help your body maintain a cellular balance.

These ions can also help move water between the fluid compartments of cells. This process is called osmosis.

However, too much or too little of some electrolytes can cause problems for your body. This can happen when your hydration levels are too low or too high and can be the root cause of conditions such as kidney disease.

Your body uses electrolytes to keep you hydrated, and they also help your brain and nerves function properly. If your electrolyte levels are out of whack, symptoms can include headache, confusion, fatigue, nausea, and vomiting.

Clotting Factors

Clotting factors are specialized proteins that help the blood to clump together to plug the site of bleeding. These proteins can be blocked or stopped with anticoagulants to prevent blood clots from forming.

Serum, on the other hand, contains only blood components without clotting factors. It is used for testing to find out whether a person has a blood disorder or an illness related to the clotting process.

Blood is drawn into evacuated tubes, with polymer stoppers color-coded to indicate which component is being collected. Plain tubes with no anticoagulant have red stoppers, while EDTA or heparin-containing tubes have purple or lavender tops.

Plasma is the liquid portion of whole blood that can be separated from the clotting fluid by centrifugation. It contains water, a suspension of white blood cells and platelets, protein, sugars, mineral salts, hormones, fats, and vitamins.


Preservatives are added to food to prevent it from spoiling by molds, yeasts, and bacteria. They are acidic in nature and prevent these unwanted organisms from growing in the food they’re added to.

Depending on the type of preservative, they can extend the shelf life of a product and also help keep foods fresh. They can also help fortify and enrich food by adding vitamins and minerals to it.

Both natural and artificial preservatives are added to food to help it last longer on the shelves or in the fridge. Some of these preservatives are good for health, but others are bad.

There are a few different kinds of preservatives, including antimicrobials, antioxidants, and enzyme inhibitors. These are often regulated by the FDA.

Plasma Vs Serum

Blood is a fluid that transports nutrients, oxygen, and metabolic wastes throughout the body. It also helps maintain the proper pH level for cellular functioning.

Serum and plasma are two different components of blood that are commonly confused with one another. In fact, both are important.

What is Plasma?

Plasma is a liquid component of your blood, containing water and proteins. It is responsible for distributing water, hormones and other substances to the parts of your body that need them.

It also contains antibodies (immunoglobulins) that help your body fight infections, protect against disease and prevent bleeding from small injuries. It also contains clotting factors that control blood loss when there are breaks in the smooth lining of your blood vessels.

Plasma is a highly complex mixture of molecules. It is composed of proteins, salts, and other chemicals. It is an important part of your blood, forming approximately 55% of your blood volume.

What is Serum?

Serum is a light, oil- or water-based liquid that you spread on your skin to get targeted skin benefits. It contains high concentrations of a single or a few key ingredients and can be used to target specific concerns like wrinkles, acne, blotchiness, or dryness.

Serum can be applied to clean skin (after cleansing and toning) before your moisturizer to deliver powerful skincare ingredients deep into your skin. This makes them a great addition to your twice-daily skincare routine.

Dermatologists Joshua Zeichner and Michelle Henry explain what serum is, how to use it, and the best products for achieving your desired results.

Basically, it’s the watery liquid that’s left behind when blood clots. It can be extracted from blood to make antiserum, which is made with antibodies from someone who has recovered from the disease to protect the person who’s recovering from it.

What is the Composition of Plasma?

Plasma makes up about 55 percent of your blood and looks like a straw-colored fluid. It carries nutrients, hormones, and waste products from different tissues to the organs responsible for detoxifying and excreting them.

It also maintains the body’s pH and osmotic load, as well as provides a defense against viruses and bacteria. It contains a variety of proteins (including the main protein albumin) and immunoglobulins that alert your immune system to foreign substances in the blood.

Composed of 90 percent water, plasma is also a rich source of lipids and salts that are essential for maintaining the body’s chemical balance. It also contains the coagulation factors and antibodies required for blood clotting.

The formed elements in plasma include erythrocytes (red blood cells), leukocytes (white blood cells), and thrombocytes (platelets). Erythrocytes transport oxygen from the lungs to the tissues and carbon dioxide back to the lungs for exhalation. Leukocytes help control the immune system. Platelets form a plug when activated that helps blood clot in the event of injury.

What is the Composition of Serum?

The composition of serum consists of water, electrolytes, glucose, proteins (albumins, globulins, fibrinogen), lipoproteins, triglycerides, and cholesterol. Serum also contains other proteins, antibodies, and nutrients.

Blood is a fluid connective tissue made up of red blood cells that carry oxygen and white blood cells that fight infections. Plasma is the liquid portion of blood and makes up 55% of the total volume of blood.

Serum consists of protein-containing liquids that have been filtered out of a blood sample after centrifugation. This separation eliminates platelets and cellular elements that might affect the test results.


Plasma is a component of blood that is yellowish in color and makes up about 55% of the blood’s volume. Plasma is mostly water and contains a variety of proteins, electrolytes, hormones, and other important molecules such as fibrinogen, which plays a key role in blood clotting. Plasma is separated from the other components of blood by spinning a blood sample in a centrifuge, which causes the blood cells to settle at the bottom of the tube, leaving the plasma at the top.

Plasma is the liquid portion of blood that remains once the cells and other components have been removed. It is a yellowish fluid that makes up about 55% of total blood volume. Plasma contains a variety of substances, including water, electrolytes, hormones, and proteins such as albumin, globulin, and fibrinogen. Plasma is important because it helps to transport nutrients, hormones, and waste products throughout the body.


Serum is the clear, yellowish fluid that remains after the blood has clotted. Like plasma, it contains a variety of proteins and other molecules, but it lacks the clotting factors that are present in plasma. Serum is obtained by allowing a blood sample to clot for about 30 minutes and then spinning it in a centrifuge to separate the serum from the clotted blood cells.

Serum, on the other hand, is the liquid component of blood that remains after the blood has clotted and the blood cells and fibrinogen have been removed. Unlike plasma, the serum does not contain clotting factors or fibrinogen, which makes it useful for certain medical tests. However, the serum does contain many of the same proteins and electrolytes as plasma, including albumin, globulin, and electrolytes like sodium and potassium.

Differences between Plasma and Serum

The main difference between plasma and serum is that plasma contains clotting factors, while serum does not. This means that, when blood is collected in a tube that contains an anticoagulant, the resulting fluid is plasma. However, when blood is allowed to clot before being spun in a centrifuge, the resulting fluid is serum. Another difference is that plasma is slightly thicker than serum due to the presence of clotting factors.

Plasma and serum are both important for medical research and diagnosis. Plasma is often used to measure the levels of various proteins and hormones in the blood, while serum is used to measure the levels of antibodies and other immune system components. In some cases, both plasma and serum may be used to obtain a more complete picture of a patient’s health.

The main difference between plasma and serum is that plasma contains clotting factors, while serum does not. This means that plasma is required for certain medical treatments, such as the treatment of bleeding disorders. However, the serum is useful for some diagnostic tests, as it does not contain clotting factors that can interfere with certain types of tests. Additionally, because plasma contains more proteins than serum, it is often used in the production of certain medications, such as immunoglobulins.

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In conclusion, while plasma and serum may seem similar, they are actually quite different in their composition and uses. Plasma is the liquid portion of blood that contains clotting factors, while serum is the liquid portion of blood that remains after clotting, and does not contain clotting factors. Both plasma and serum are important components of blood, and their differences allow for their use in different medical settings. Understanding these differences can help healthcare professionals make more accurate diagnoses and provide better treatment for their patients.

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